Rethinking a Cure for Alzheimer's Disease

Medicare Part D - Rethinking a Cure for Alzheimer's Disease

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A recent record in Journal of Alzheimer's Disease discussed any inconvenient facts on the state of Alzheimer's research, namely that the practically particular focus on amyloid beta protein as the cause of Alzheimer's Disease (Ad) has produced a considerable string of failures in drug trials that target dismissal of amyloid beta in the brain.

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Medicare Part D

Authored by Daniel George, a investigate professor at Penn State, the record points to a tentative but growing confidence that the curative investigate and pharmaceutical industries might need to take a step back and look at the Ad question from a fresh viewpoint. The details on why amyloid beta may only end up being a moderately beneficial biomarker for Ad and nothing more, I'll save for a hereafter story.

What I will do is try to say what the two main parts of a new conceptual framework could look like:

1. Alzheimer's Disease is an age-related broad spectrum condition, not a particular disease.

The "upstream" factors that can conduce to Ad comprise personal genetics, lifestyle choices (diet, exercise, smoking, etc), plus a history of brain injuries and other maladies that furnish long term brain inflammation. In other words, a person's lifestyle and curative history over any decades will greatly sway the chances of Alzheimer's.

2. Alzheimer's Disease may end up being a chronic but manageable condition, much like diabetes or hypertension.

This is a determined way of saying that an outright cure for Ad may never happen, but that (future) medications could reliably slow or delay symptoms of cognitive decline for, say 8-10 years. Fantasize a sick person at age 70, on the edge of Alzheimer's, being able to take a new medication that gives her the quality continue to live independently for any more years. The possible for an improved quality of life is huge, not to mention the substantial taxpayer savings through Medicare if millions of seniors do not require full time care.

The curative expedient manufactures has started to put more resources into developing early detection and screening tests for Alzheimer's. There are any computerized cognitive condition screening tools that can be used in the doctor's office, which will come to be more prevalent now that the Medicare yearly Wellness Visit advantage is in place.

There are also any biomarker tests in development, including spinal fluid and blood tests. However, these tests are experimental and have important drawbacks and/or conflicting results at this point. I believe it will take a few years to shake out what a "routine" screening process for Ad could look like. In the meantime, the Alzheimer's investigate society and pharmaceutical clubs have their work cut out to shape out a way forward after any disappointing Phase Iii drug trial results.

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